A série enfoca a dinâmica entre os colegas de apartamento, os físicos Leonard e Sheldon, e a nova vizinha do prédio, a bela Penny, que desperta a atenção de Leonard à primeira vista. Leonard e Sheldon recebem frequentemente a visita de seus dois amigos e também colegas de trabalho na Universidade, Rajesh e Howard, e juntos usam o tempo livre para todo tipo imaginável de divertimento nerd: de palavras cruzadas em idioma Klingon, passando por maratonas de séries de ficção científica às sagradas noites de quarta jogando Halo. Penny aos poucos vai se integrando a esse estranho novo ambiente, onde ouve discussões sobre a física do super-homem e mecânica quântica, enquanto os intelectuais são apresentados a novos conceitos, como o amor.

1×00 – Pilot -> Hotfile (Este é um episódio piloto da série produzido cerca de um ano antes dela ir ao ar que vazou recentemente na internet)

1×01 – Pilot -> Hotfile
1×02 – The Big Bran Hypothesis -> Hotfile
1×03 – The Fuzzy Boots Corollary -> Hotfile
1×04 – The Luminous Fish Effect -> Hotfile
1×05 – The Hamburger Postulate -> Hotfile
1×06 – The Middle Earth Paradigm -> Hotfile
1×07 – The Dumpling Paradox -> Hotfile
1×08 – The Grasshopper Experiment -> Hotfile
1×09 – The Cooper-Hofstadter Polarization -> Hotfile
1×10 – The Loobenfeld Decay -> Hotfile
1×11 – The Pancake Batter Anomaly -> Hotfile
1×12 – The Jerusalem Duality -> Hotfile
1×13 – The Bat Jar Conjecture -> Hotfile
1×14 – The Nerdvana Annihilation -> Hotfile
1×15 – The Pork Chop Indeterminacy. -> Hotfile
1×16 – The Peanut Reaction -> Hotfile
1×17 – The Tangerine Factor (Season Finale) -> Hotfile

2ª Temporada (RMVB Legendado)

2×01 – The Bad Fish Paradigm -> Hotfile
2×02 – The Codpiece Topology -> Hotfile
2×03 – The Barbarian Sublimation -> Hotfile
2×04 – The Griffin Equivalency -> Hotfile
2×05 – The Euclid Alternative -> Hotfile
2×06 – The Cooper-Nowitzki Theorem -> Hotfile
2×07 – The Panty Piñata Polarization -> Hotfile
2×08 – The Lizard-Spock Expansion -> Hotfile
2×09 – The White Asparagus Triangulation -> Hotfile
2×10 – The Vartabedian Conundrum -> Hotfile
2×11 – The Bath Item Gift Hypothesis -> Hotfile
2×12 -The Killer Robot Instability -> Hotfile
2×13 – The Friendship Algorithm -> Hotfile
2×14 – The Financial Permeability -> Hotfile
2×15 – The Maternal Capacitance -> Hotfile
2×16 – The Cushion Saturation -> Hotfile
2×17 – The Terminator Decoupling -> Hotfile
2x18 – The Work Song Nanocluster -> Hotfile
2×19 – The Dead Hooker Juxtapositio -> Hotfile
2×20 – The Hofstadter Isotope -> Hotfile
2×21 – The Vegas Renormalization -> Hotfile
2×22 – The Classified Materials Turbulence -> Hotfile
2×23 – The Monopolar Expedition (Season Finale) -> Hotfile

3ª Temporada (RMVB Legendado)

3×01 – The Electric Can Opener Fluctuation -> Hotfile
3×02 – The Jiminy Conjecture -> Hotfile
3×03 – The Gothowitz Deviation -> Hotfile
3×04 – The Pirate Solution -> Hotfile
3×05 – The Creepy Candy Coating Corollary -> Hotfile
3×06 – The Cornhusker Vortex -> Hotfile
3×07 – The Guitarist Amplification -> Hotfile
3×08 – The Adhesive Duck Deficiency -> Hotfile
3×09 – The Vengeance Formulation -> Hotfile
3×10 – The Gorilla Experiment -> Hotfile
3×11 – The Maternal Congruence -> Hotfile
3×12 – The Psychic Vortex -> Hotfile
3×13 – The Bozeman Reaction -> Hotfile
3×14 – The Einstein Approximation -> Hotfile
3×15 – The Large Hadron Collision -> Hotfile
3×16 – The Excelsior Acquisition -> Hotfile
3×17 – The Precious Fragmentation -> Hotfile
3×18 – The Pants Alternative -> Hotfile
3×19 – The Wheaton Recurrence -> Hotfile
3×20 – The Spaghetti Catalyst -> Hotfile
3×21 – The Plimpton Stimulation -> Hotfile
3×22 – The Staircase Implementation -> Hotfile
3×23 – The Lunar Excitation (Season Finale) -> Hotfile